Statistical genetics

Statistical methods for genome-wide association studies, heritability estimation from summary statistics, fine-mapping, Mendelian randomization and gene constraint scores.

• Bayesian fine-mapping and colocalization
• BOLT-LMM mixed-model association
• Gene constraint scores (pLI and LOEUF)
• Imputation of association summary statistics
• Latent causal variable model
• LD-score regression
• Genomic prediction from summary statistics
• Mendelian randomization
• Posterior of the heterozygous selection coefficient
• Principal-component correction for stratification
• Proximal contamination in mixed-model association
• Signed LD profile regression
• Stratified LD-score regression
• Testing LD consistency of association statistics

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